Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-endo-BCN (MW 2000) | 93.3% | 2000 | 5 MG
DSPE-PEG-endo-BCN (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. It is suitable for use in drug delivery research.
- Peg lipid
- Can improve delivery efficiency of poorly soluble drugs
- Can improve tissue specificity of poorly soluble drugs
- Suitable for drug delivery research
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | >98% | C32H44F4N2O13 | 1 G
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which facilitate the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
eMolecules 2182602-22-6 | Mal-amido-PEG9-amine TFA salt | Broadpharm607.698 | C27H49N3O12 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 368397735
Mal-amido-PEG9-amine TFA salt | Broadpharm | 2182602-22-6607.698 | C27H49N3O12 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 368397735
eMolecules 2055041-16-0 | Bromoacetamido-PEG8-t-butyl ester | Broadpharm | MFCD29918248 | 618.559 | C25H48BrNO11 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 500mg | 550804297
Bromoacetamido-PEG8-t-butyl ester | Broadpharm | 2055041-16-0 | MFCD29918248 | 618.559 | C25H48BrNO11 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 500mg | 550804297
Medchemexpress LLC Methyltetrazine-PEG24-NHS ester | 00-00-0 | 99.3% | C64H111N5O29 | 10MG
Methyltetrazine-PEG24-NHS ester is a PEG24 linker bearing a methyltetrazine reactive moiety and an N-hydroxysuccinimide (NHS) activated ester. Provided as a dry research reagent, it is designed for bioconjugation and PROTAC linker synthesis, enabling rapid bioorthogonal ligation to trans-cyclooctene (TCO) derivatives and stable amide bond formation with primary amines. The long PEG24 spacer enhances aqueous solubility and provides flexibility between conjugated components.
- Enables rapid inverse electron-demand Diels-Alder (IEDDA) conjugation with TCO reagents.
- Provides an NHS ester for efficient coupling to primary amines.
- PEG24 spacer increases aqueous solubility and linker flexibility.
- High purity suitable for research applications.
- Supplied in mg-scale packages for small-scale conjugations.
- Intended for research use only and not for human therapeutic use.
Medchemexpress LLC Dbco-peg5-dbco | 2363130-04-3 | MFCD28334545 | 98.0% | C50H54N4O9 | 10MG
DBCO-PEG5-DBCO is a bifunctional PEG-based linker bearing two dibenzocyclooctyne (DBCO) groups designed for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and for use as a flexible spacer in bifunctional molecule assembly, such as linker-mediated conjugates and PROTAC synthesis.
- Enables copper-free SPAAC click conjugation to azide-containing molecules.
- Provides a PEG5 spacer to improve solubility and flexibility of conjugates.
- Offers two reactive DBCO termini for symmetric conjugation or crosslinking.
- High purity (98.0%) suitable for research-grade synthesis.
- Available in small-quantity packs to support lab-scale experimentation.
Medchemexpress LLC Tco-PEG5-maleimide | 00-00-0 | 99.5% | C28H45N3O10 | 10MG
TCO-PEG5-maleimide is a PEG-based PROTAC linker and click-chemistry reagent that combines a maleimide reactive group with a PEG5 spacer bearing a trans-cyclooctene (TCO) moiety. It is designed for efficient bioorthogonal conjugation and thiol-selective coupling in PROTAC synthesis and bioconjugation workflows, provided as a high-purity solid with recommended low-temperature storage for stability.
- Enables rapid bioorthogonal conjugation via TCO-tetrazine click chemistry.
- Maleimide group allows thiol-selective conjugation to cysteine residues or thiol-containing linkers.
- PEG5 spacer improves aqueous solubility and reduces steric hindrance.
- High chemical purity suitable for synthesis and analytical applications.
- Available in multiple small-scale package sizes for research use.
- Stable when stored dry at low temperature; in solution requires colder storage for extended stability.
Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-(2-azidoethoxy)ethoxy]ethyl] hexahydro-2-oxo- | 1910803-72-3 | 97.0% | 100 MG
Biotin-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent with an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 25 MG
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group molecules.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC Alkyne-cRGD | 2665674-77-9 | 99.48% | 713.78 | 5 MG
Alkyne-cRGD is an integrin ligand that can be used in the study of degraders. It undergoes copper-catalyzed azide-alkyne cycloaddition reaction. It is characterized by a purity of 99.48% and is supplied as a white to off-white solid.
- Functions as an integrin ligand
- Useful in the study of degraders
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction
- High purity of 99.48%
- Supplied as a white to off-white solid
CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183527.JPG-250.jpg)
eMolecules 2250217-32-2 | TCO-PEG3-triethoxysilane | Broadpharm576.803 | C27H52N2O9Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547
TCO-PEG3-triethoxysilane | Broadpharm | 2250217-32-2576.803 | C27H52N2O9Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547
Cayman Chemical GefItInIb-based PROTAC 3 25mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Cayman Chemical ANTIBODY DBCO acId 50mg
A copper-free click chemistry reagent; has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro; has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to induce cytotoxicity and reduce tumor growth, respectively
Medchemexpress LLC Mpro inhibitor N3 hemihydrate | MFCD00274570 | 99.9% | 698.81 | C35H50N6O9 | 5 MG
Mpro inhibitor N3 hemihydrate is a small-molecule inhibitor of coronavirus main protease (Mpro) provided as a white to off-white solid hemihydrate for biochemical and antiviral research; product page lists purity, storage, and solubility information for experimental planning.
- Potent inhibitor of coronavirus main protease with reported cellular activity.
- High purity (99.86%).
- Supplied as a white to off-white solid hemihydrate.
- Stable when stored as powder at -20°C for up to 3 years.
- High solubility in DMSO (100 mg/mL) suitable for in vitro assays.
- Formulated for small-scale research applications.